Pharmacy Exam Points (to remember)... Set 26

1. The most prominent and dose related side effect of salbutamol is Β₂-mediated skeletal muscle tremors.
2. In a patient of bronchial asthma, Salbutamol is the fastest acting inhaled bronchodilator, which aborts or terminates asthma attacks.
3. Leukotriene (cys LT1, i.e. Cysteinyl leukotriene receptor 1) receptor antagonists is the class of drugs that are clinically beneficial in bronchial asthma.
4. Salmeterol is a long-acting selective β-2 agonist bronchodilator.
5. Theophylline use in asthma has declined because of narrow safety margin.
6. Relatively higher dose of theophylline is required to attain therapeutic plasma concentration in smokers.
7. Bambuterol is a long-acting β adrenoceptor agonist (LABA) used in the treatment of asthma.
8. Bambuterol is an orally acting bronchodilator, a prodrug of terbutaline and inhibits the enzyme pseudocholinesterase.
9. Methylxanthines exert the following actions at cellular or molecular level: causes intracellular release of Ca2+, blockade of adenosine receptors and inhibition of phosphodiesterase (PDE) enzyme which breaks down cAMP into AMP.
10. Caffeine is a commonly used neurostimulant that also produces cerebral vasoconstriction by antagonizing adenosine receptors which reduces cerebral blood flow.