Note: Answer keys are given at the end of the MCQs.
a- 50 mg
b- 100 mg
c- 500 mg
d- 2500 mg
e- 5000 mg
802. A new drug is being tested for its effectiveness against a certain disease through a randomized controlled trial. It has been found that the disease complicates by 10% in the intervention group and by 30% in the controlled group. Calculated the relative risk reduction with this new drug?
a- 20%
b- 10%
c- 33%
d- 40%
e- 67%
803. Isomers that are neither the mirror images of each other and nor are superimposable are referred to as;
a- enantiomers
b- diastereomers
c- meso isomers
d- stereoisomers
e- chain isomers
804. If a compound has 2 chiral centers, how many optical isomers are possible for this particular compound?
a- none
b- one
c- two
d- three
e- four
805. In a randomized controlled trial conducted over a period of one year, a serious side effect is being observed with the conventional therapy for a certain disease in 1 percent of the study group while with a newly discovered drug only 0.5 percent of the group experience the same side effect. Calculate NNT (i.e the minimum number of patients that must be treated for a year with the novel drug so that at least one patient is benefited from the therapy)?
a- 10
b- 20
c- 100
d- 200
e- 2000
806. A combination product of buprenorphine and naloxone is prescribed for the management of opioid misuse syndrome. How buprenorphine works in this combo to achieve the desired goal?
a- kappa receptor weak antagonism
b- mu receptor strong agonism
c- kappa receptor strong agonism
d- mu receptor partial agonism
e- both a and d
807. Winter-Tozer equation is used in patients of hypoalbuminemia for the dose adjustment of;
a- haloperidol
b- halothane
c- phenytoin
d- phenobarbital
e- doxorubicin
808. Figure out the WRONG statement from among the following;
a- omeprazole is used in the treatment of indigestion
b- the majority of urinary tract infections are caused by E. coli
c- oil of citronella is used as an insect repellent
d- walking is an example of weight-bearing exercise
e- pharmaceutical packaging materials do not require quality control tests
809. Medication that can contribute to urinary incontinence in a geriatric patient is;
a- bumetanide
b- verapamil
c- lisinopril
d- digoxin
e- memantine
810. Calculate the steady-state concentration of an intravenously administered drug if its rate of infusion is 800 mg every 8 hours and the rate of clearance is 8 liters per hour?
a- 12.5 mg/L
b- 25 mg/L
c- 100 mg/L
d- 125 mg/L
e- 250 mg/L
811. A 40-year-old diabetic woman is using glipizide as part of her antidiabetic therapy. Recently she has been diagnosed with urinary tract infection for which the doctor prescribed cotrimoxazole. As a pharmacist, is there anything to be concerned about the medications that she is going to take?
a- no need to worry, the prescription is safe to administer
b- cotrimoxazole can increase the hypoglycemic effect of glipizide
c- glipizide reduces the therapeutic efficacy of cotrimoxazole
d- just switch glipizide to glimepiride, rest is all right
e- cotrimoxazole is contraindicated in diabetic patients
812. Clopidogrel should not be given along with one of the following proton pump inhibitors as there is an interaction between the two which renders the clopidogrel ineffective;
a- omeprazole
b- rabeprazole
c- lansoprazole
d- pantoprazole
e- all PPIs are contraindicated with clopidogrel
813. Hyperkalemia can put a patient at the risk for;
a- muscles wasting
b- hemolysis
c- thromboembolism
d- cardiac arrhythmias
e- hypotension
814. Selective Serotonin Reuptake Inhibitors (SSRIs) class of anti-depressants should not be discontinued abruptly as they will cause the withdrawal syndrome. But there is one SSRI that is an exception to this rule. Identify which one?
a- paroxetine
b- citalopram
c- fluoxetine
d- escitalopram
e- dapoxetine
815. Hyperventilation is a condition in which one is breathing very fast. This can lead to;
a- no change in blood CO2 levels and pH
b- rise in blood CO2 levels with lowering of pH
c- rise in blood CO2 levels with an elevation of pH
d- lowered blood CO2 levels with a drop in pH
e- lowered blood CO2 levels with rising in pH
816. The last resort antipsychotic (i.e. patients who fail to get useful results with other antipsychotics) is;
a- risperidone
b- clozapine
c- olanzapine
d- quetiapine
e- haloperidol
817. The main toxicity of methanol is due to the formation of which toxic metabolite?
a- oxalic acid
b- formic acid
c- lactic acid
d- acetic acid
e- trichloromathanol
818. A patient weighing 180 pounds is to be given IV infusion of a medicine for over 6 hours. The target plasma concentration is 16 mg/dL. Knowing the half-life of this medicine to be 4 hours and the apparent volume of distribution to be 6 liters, the rate of infusion for this patient will be;
a- 166.32 mg/hr
b- 96.4 mg/hr
c- 364.8 mg/hr
d- 238.92 mg/hr
e- 16.0 mg/hr
819. To a Parkinson's disease patient one of the following medications is not recommended as it can worsen the disease status;
a- benztropine
b- olanzapine
c- magnesium supplements
d- MAO inhibitors
e- galantamine
820. Dopamine exerts dose-dependent effects. At 2 micrograms, it will produce the effect of;
a- diuresis
b- positive inotropic effect
c- vasoconstriction
d- all of the above
e- at such a low dose, it has no effect at all
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Answer Keys
MCQ # - Correct option
801 - d
802 - e
803 - b
804 - e
805 - d
806 - e
807 - c
808 - e
809 - a
810 - a
811 - b
812 - a
813 - d
814 - c
815 - e
816 - b
817 - b
818 - a
819 - b
820 - a
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